منابع مشابه
The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK.
Riluzole (RP 54274) is a potent neuroprotective agent with anticonvulsant, sedative, and anti-ischemic properties. It is currently used in the treatment of amyotrophic lateral sclerosis. This article reports that riluzole is an activator of TREK-1 and TRAAK, two important members of a new structural family of mammalian background K(+) channels with four transmembrane domains and two pore region...
متن کاملThe two-pore-domain K(+) channels TREK-1 and TASK-3 are differentially modulated by copper and zinc.
The "trace" elements copper and zinc are essential for life, and their role in the function of metalloproteins is well known. However, mounting evidence shows that these metals are also capable of modulating neuronal excitability under normal physiological conditions. They are present at high levels in the brain, are concentrated at nerve terminals, and are released at micromolar concentrations...
متن کاملExpression of tandem P domain K+ channel, TREK-1, in the rat carotid body.
TREK-1 is one of the important potassium channels for regulating membrane excitability. To examine the distribution of TREK-1 in the rat carotid body, we performed RT-PCR for mRNA expression and in situ hybridization and immunohistochemistry for tissue distribution of TREK-1. RT-PCR detected mRNA expression of TREK-1 in the carotid body. Furthermore, in situ hybridization revealed the localizat...
متن کاملStarring TREK-1: the next generation of vascular K+ channels.
“We are more alike than unlike, my dear Captain. I have pores, humans have pores.” Lieutenant Commander Data, Stardate 41209.2 Before 1996, all known mammalian K channels were classified into only two different structural families according to the number of transmembrane (TM) spanning and pore-forming (P) domains in their subunit. One family is characterized by K channels composed of two TM dom...
متن کاملFormation of Functional Heterodimers by TREK-1 and TREK-2 Two-pore Domain Potassium Channel Subunits.
Two-pore domain (K2P) potassium channels are the major molecular correlates of the background (leak) K(+) current in a wide variety of cell types. They generally play a key role in setting the resting membrane potential and regulate the response of excitable cells to various stimuli. K2P channels usually function as homodimers, and only a few examples of heteromerization have been previously re...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2002
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2001.014829